Vitreo Retina
Commentary: All India Ophthalmological Society members' survey: Practice pattern of intravitreal anti-vascular endothelial growth factor injection" has been published in "Indian Journal of Ophthalmology
, Department of Vitreo Retina
The strength o f the study is the large number o f
specialists (741) who have responded to the questionnaire.
It is interesting to note that practices like wearing of gloves,
use of mask, and eye speculum is more or less a universal
practice and is similar to that of developed countries.[1,2]
It further emphasizes that ophthalmologists in India are
conscious of sterile practices. Some of the practices like use
of prophylactic antibiotics and post‑treatment antibiotics
are also similar to what is followed in the US and UK.[1,2]
The survey surprisingly does not mention about the use of
topical povidone–iodine prior to the injection which I feel
is a universal practice. It would have been interesting if the
survey had looked into certain important aspects regarding
the injection techniques viz.
(a) Size of needle used
(b) Displacement of the conjunctiva at the time of injection
(c) Quadrant used for performing the injection
(d) Paracentesis at the end of the procedure
(e) Is checking the peripheral retina a routine practice prior to
the injection
(f) Does the ophthalmologists check forretinal perfusion at the
end of the procedure
(g) Is pupillary dilatation a routine practice priorto the injection
(h) Bilateral simultaneous injection – is it a practice in our
country as it is very common in the UK and nearly 40% of
the respondents in the US perform bilateral injection.[3]
(i) Whatis an average time gap when both eyes need treatment?
(j) When do ophthalmologists examine the patient after the
injection procedure?
The survey has looked into the injection practices for use of
bevacizumab (Avastin). This is a very important contribution.
In spite of the recommendations of AIOS–VRSI guidelines,[4]
there are still a sizeable number of ophthalmologists who
are following the multiple puncture technique. It is also
disheartening to note that 1/5th of the respondents are storing
the open vials and loaded syringes up to one month in the
refrigerator. In a developing country like ours bevacizumab
will continue to be an important anti‑VEGF agent in vitreo
retina practice and although aliquoting techniques are
difficult we need to be careful to prevent post‑injection
endophthalmitis. In a recent report from our center where
we evaluated 3806 injections of bevacizumab with proper
aliquoting technique, the incidence of endophthalmitis was
only 0.08%.[5]
With increasing number of ophthalmologists practicing intravitreal injection, it is necessary for the AIOS and VRSI to continuously update ophthalmologists about the safe and clean practices. It will also be useful fortheAIOS to bring out a video on safe practices in administering intravitreal injections as part of the CME series in collaboration with VRSI